Arylcyclohexylamin comprised of an amine moiety and an aromatic ring attached to a cyclohexane ring.
Arylcyclohexylaminesare believed to make their effects primarily by antagonism of NMDA receptors.Antagonism of the NMDA receptor confers anesthetic, anticonvulsant , and dissociative effects. Contrary to popular belief, most arylcyclohexylaminesdo not significantly inhibit re-uptake of dopamine or agonise μ-opioid receptors.
An arylcyclohexylamineis composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine . In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary; secondary amines such as methylamino or ethylamino, or tertiary cycloalkylamines such as piperidino and pyrrolidino , are the most commonly encountered N-substituents.